Game Predictions | Buffalo Bills at Indianapolis Colts

The Buffalo Bills are flying a bit under the radar. They haven’t played in a nationally televised game since beating the New York Jets in Week 6. Buffalo has won four consecutive games, averaging 29.5 points in that span, and it has the second-best record in the AFC.

Meanwhile, the Indianapolis Colts have scratched and clawed their way to a mediocre 4-5 record. They’re trying to spark the offense with 39-year-old quarterback Joe Flacco, who struggled against the Minnesota Vikings’ 28th-ranked pass defense last week. He finished 16-of-27 for 179 yards, no touchdowns and one interception.

Based on the recent trends, the Bills are the side to take in this matchup. O’Donnell agrees with that perspective.

“The last thing the Colts’ QB quagmire needs is a visit from a team with an MVP front-runner,” O’Donnell said. “And they get just that with Josh Allen coming to town.”

“Indy’s defense is giving up nearly 384 yards per game. The Bills have a top-five scoring offense with no real weaknesses. I won’t be fooled by the divisional nail-biter last week and think less of Buffalo. This game shouldn’t be close.”

Sobleski also backed the Bills.

“The Bills going into Indianapolis and essentially getting a seven-point swing in their favor is a direct indictment of the Colts’ recent decision-making process. That isn’t to say that Anthony Richardson is a difference-maker who could have changed the line. Rather, it’s a reflection of how the Flacco move turned out to be a complete disaster.

Indianapolis can do far better than the 227 total yards and six offensive points that it tallied against the Vikings. But the 39-year-old statuesque quarterback will be playing behind two rookie interior linemen. Unless Jonathan Taylor somehow finds running room against Buffalo, it’s hard to see this game even being close.”

Score Prediction: Bills 27, Colts 20